Can Food Allergies Go Away? Understanding Natural Tolerance Development

Over 32 million Americans are affected by food allergies. While strict avoidance is currently the primary management strategy, research shows some allergies may naturally resolve over time.

Resolution Rates

Milk ~80% by age 16

Egg ~70% by age 16

Soy ~60% in children

Peanut ~20% resolution

Tolerance Mechanisms

Oral Tolerance

Gradual exposure reprograms immune response

IgE Reduction

Antibody levels fall below reaction threshold

Immune Maturation

Gut microbiome diversity increases

Favorable Resolution Factors

Age

Earlier diagnosis improves odds

Severity

Milder initial reactions

IgE Levels

Lower specific antibodies

Health

No other allergic conditions

Treatment Approaches

Oral Immunotherapy

Up to 80% success rate with graduated exposure

Epicutaneous Therapy

50% success using skin patches

Anti-IgE Treatment

Neutralizes antibodies to reduce reactions

Post-Remission Precautions

• Never reintroduce foods without medical supervision
• Confirm tolerance through clinical food challenges
• Maintain regular consumption after clearance
• Monitor IgE levels periodically
• Stay prepared for potential recurrence

Note: This information is for educational purposes only. Always consult with an allergist for personalized medical advice regarding food allergy management.