Food Allergies and Genetics: Understanding Inheritance Patterns
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According to recent genome-wide association studies, food allergies involve complex genetic patterns rather than simple dominant or recessive inheritance, with multiple genes and environmental factors playing crucial roles.
Twin Studies Evidence
Identified Genetic Factors
HLA Genes
- • HLA-DQ variants: 3.2x increased risk
- • HLA-DR variants: 2.1x increased risk
Family Risk Patterns
First-Degree Relatives
- • Peanut: 7x increased risk
- • Milk: 4x increased risk
- • Egg: 2x increased risk
Evidence-Based Prevention Strategies
Key References
Genome-Wide Association Studies (2021)
Comprehensive genetic analysis of food allergy inheritance
JAMA Pediatrics Twin Study (2020)
Large-scale twin concordance analysis
Nature Reviews Immunology (2021)
HLA associations in food allergy